In the infamous study where the genetic predisposition for cancer was called out, researchers were using the Sprague-Dawley strain of laboratory rat. 2017 01 31; 114(5):E859-E868. Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty. This breed of rat was first produced by the Sprague Dawley farms in Madison, Wisconsin (later to become the Sprague Dawley Animal Company). (Harvard PROFILES RNS software version: 2.11.1). Sci Rep. 2020 01 24; 10(1):1136. It has a high reproductive rate and low incidence of spontaneous tumors. PLoS One. Authors Ying Piao 1 , Yunen Liu, Xiaodong Xie. Contact Us It was developed by the Sprague-Dawley Animal Company. J Vasc Surg. B01.050.150.900.649.313.992.635.505.700.750. Hirata H, Mizerska K, Dallacasagrande V, Rosenblatt MI. SAS Sprague Dawley Rat … 2020 05 01; 201(9):1120-1134. BPA was administered to pregnant Crl:CD BR Sprague-Dawley rats by gavage at 0, 3.2, 32, or 320 mg/kg/day from gestation day (GD) 11 through postnatal day (PND) 20. The rats average about 5 grams of food per day per 100 grams of body weight and about 10-12 milliliters of water per 100 grams of body weight. Below are the most recent publications written about "Rats, Sprague-Dawley" by people in Profiles. 2020 04; 71(4):1378-1389.e3. Interestingly, the Sprague-Dawley rats had the highest percentage (87%) to develop thermal allodynia following contusion SCI, while 100% of both Long-Evans and Sprague Dawley rats developed thermal allodynia in the hemisection model. Decreases in sperm motility and/or increased abnormal sperm were noted in mice, but not in rats, exposed to 3 mg/m 3 or more in 13-week inhalation studies with cobalt sulfate (National Toxicology Program, 1991). Tyburski AL, Cheng L, Assari S, Darvish K, Elliott MB. By contrast, outbred populations are used when identical genotypesare unnecessary or a population with genetic variation is required, and these rats are usually referred to as stocks rather than … U.S. Department of Health and Human Services . The colony then went to Sprague Dawley, Inc. in 1945. Fong LY, Jing R, Smalley KJ, Wang ZX, Taccioli C, Fan S, Chen H, Alder H, Huebner K, Farber JL, Fiehn O, Croce CM. Liver S9 fractions prepared from a pool of male Sprague Dawley rats. Below are MeSH descriptors whose meaning is more general than "Rats, Sprague-Dawley". 7 Am J Respir Crit Care Med. November 2018 . Consortium, The Regents of the University 2020 06; 125(6):911-919. Top journals in which articles about this concept have been published. Estimating the Osmolarities of Tears During Evaporation Through the "Eyes" of the Corneal Nerves. It was developed by the Sprague-Dawley Animal Company. It is the most widely used rat model for biomedical research. Rederived into isolator foundation colony in 1997. Plast Reconstr Surg. Diffusion Magnetic Resonance Imaging Predicts Peripheral Nerve Recovery in a Rat Sciatic Nerve Injury Model. Top journals in which articles about this concept have been published. Braz J Med Biol Res. Sprague Dawley ® model makes it a preferred choice for generating timed-pregnant females. Sprague Dawley Rat High Fat T Increases Pain Behaviors In Rats With Or Without Significance of malondialdehyde superoxide diase and tary factors in fasting blood glucose levels and weight gain charles river 2019 research models services us rnu rat charles river parison of two protocols carbon tetrachloride induced "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. J Invest Dermatol. of Colorado, a body corporate. 2018 11 20; 115(47):E11091-E11100. Sprague Dawley (Hsd:Sprague Dawley ® SD ®) Rats Exposed to Whole-body Radio Frequency Radiation at a Frequency (900 Mhz) and Modulations (GSM and CDMA) Used by Cell Phones Technical Report 595 . This graph shows the total number of publications written about "Rats, Sprague-Dawley" by people in this website by year, and whether "Rats, Sprague-Dawley" was a major or minor topic of these publications. 2018 04 02; 28(7):1079-1089.e4. Taconic’s proven process ensures timed-pregnant rats bear litters within a 24-hour window of your desired gestational age. To see the data from this visualization as text. We have created the immunodeficient SRG rat, a S prague-Dawley Rag2/Il2rg double knockout that lacks mature B cells, T cells, and circulating NK cells. This breed of rat was first produced by the Sprague Dawley farms (later to become the Sprague … which enables searching at various levels of specificity. This model has been tested and validated for use in oncology (SRG OncoRat®). Sprague Dawley rats were first bred by the Sprague Dawley farm in Madison, Wisconsin in 1925 through multiple crosses with a single-hooded male and six albino female rats. Seedorf G, Kim C, Wallace B, Mandell EW, Nowlin T, Shepherd D, Abman SH. Sprague-Dawley rats were treated with vehicle or rapamycin (2 mg/kg/day) for 15 days. Mean, standard deviation, median interquartile range … Hence, this study aimed to investigate the anti-obesity activity of Elateriospermum tapos (E. tapos) shell extract in obesity induced Sprague Dawley rats. The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical research. Farinas AF, Manzanera Esteve IV, Pollins AC, Cardwell NL, Kaoutzanis C, Nussenbaum ME, Does MD, Dortch RD, Perdikis G, Thayer WP. Gibco Primary Rat Cortex Neurons, Sprague Dawley, are isolated and cryopreserved from Sprague Dawley embryonic day-18 rats. When your research demands versatility and consistency, turn to the Sprague . J Headache Pain. The strain was created by R. W. Dawley in 1925, from a hooded male hybrid of unknown origin and an albino female (probably Wistar), and was crossed with the female’s progeny for 7 generations. Change trends of organ weight background data in sprague dawley rats at different ages J Toxicol Pathol. Temporomandibular inflammation mobilizes parvalbumin and FosB/deltaFosB neurons of amygdala and dorsal raphe. If you have any questions or feedback please contact us. 2020 04 08; 40(15):2993-3007. 2020 08 01; 319(2):G157-G169. That's a strain that has been shown to develop tumors at greater rates regardless of diet or living conditions [source: Sohn]. Hirsch K, Taglauer E, Seedorf G, Callahan C, Mandell E, White CW, Kourembanas S, Abman SH. 2017 Dec; 37(14):1350-1372. Descriptors are arranged in a hierarchical structure, By having this kind of population, it is possible to conduct experiments on the roles of genes, or conduct experiments that exclude variations in genetics as a factor. In male rats, which are commonly used for permeability estimation, there were differences for Metoprolol permeability between Sprague-Dawley (with lower permeability values) and the other strains, while for Verapamil Sprague-Dawley and Wistar-Han showed the lower permeability values. All rights reserved. In 1991, 8 colonies were selected to form the IGS Foundation Colony. Li Q, Kingman J, van de Wetering K, Tannouri S, Sundberg JP, Uitto J. Abcc6 Knockout Rat Model Highlights the Role of Liver in PPi Homeostasis in Pseudoxanthoma Elasticum. So yes, some laboratory rats … 2020 10 15; 202(8):1146-1158. Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats. Invest Ophthalmol Vis Sci. rhIGF-1/BP3 Preserves Lung Growth and Prevents Pulmonary Hypertension in Experimental Bronchopulmonary Dysplasia. Sprague Dawley rats in health. 2020 04; 145(4):949-956. Below are MeSH descriptors whose meaning is more specific than "Rats, Sprague-Dawley". of Colorado. studied the development of the hair follicle in individuals that displayed the hairless phenotype. Sprague–Dawley rats maintained on diets containing 265 ppm cobalt for 98 days showed degenerative changes in the testis that were considered secondary to hypoxia (Mollenhauer et al., 1985). The Sprague Dawley® outbred model was developed by Sprague Dawley, Inc. NIH received stock from Am J Physiol Gastrointest Liver Physiol. Musah AS, Brown TL, Jeffries MA, Shang Q, Hashimoto H, Evangelou AV, Kowalski A, Batish M, Macklin WB, Wood TL. 2020 05; 124(5):603-613. National CTSA Br J Anaesth. "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Dawley ® outbred rat model. Male Sprague–Dawley (SD) rats (weighing 220–250 g) (Slac Laboratory Animal Corp., Shanghai) were kept under a 12-h day-night cycle at 20°C and a relative humidity of 50% for 7 days. A flexible, ready-to-use, and quality alternative to fresh neurons, each vial contains one million cells per mL. National Toxicology Program . Kadekawa K, Kawamorita N, Shimizu T, Kurobe M, Turnbull PS, Chandra S, Kambara T, Barton JC, Russell AJ, Yoshimura N. Effects of a selective androgen receptor modulator (SARM), GSK2849466A, on stress urinary incontinence and bladder activity in rats with ovariectomy-induced oestrogen deficiency. 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