Adenine nucleotide translocase-2 (ANT2), one of the four adenine nucleotide translocase isoforms expressed in humans, is expressed at high levels in undifferentiated cells and tissues with high pro-liferating and regenerating capacity, including lympho-cytes, kidney, and liver [14-16]. In the beginning of apoptosis, death signals (anti-tumor compounds, superoxide, etc.) GSAO (4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid) and PENAO (4-(N-(S-penicillaminylacetyl)amino) phenylarsonous acid) are tumour metabolism inhibitors that target adenine nucleotide translocase (ANT) of the inner-mitochondrial membrane. Organic & Biomolecular Chemistry 2010 April 7, 8 (7): 1520-2. A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates. GSAO (4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid) and PENAO (4-(N-(S-penicillaminylacetyl)amino) phenylarsonous acid) are tumour metabolism inhibitors that target adenine nucleotide translocase (ANT) of the inner-mitochondrial membrane. ADP/ATP translocase 2 is a protein that in humans is encoded by the SLC25A5 gene on the X chromosome. Mol Cancer Ther 15: 1387-1396. We demonstrate that MT-21 significantly inhibits ADP transport activity in mitochondria and reduces binding of the adenine nucleotide translocase (ANT) to a phenylarsine oxide affinity matrix. ANT exclusively transports adenine nucleotides, such as ADP and ATP, by an antiport mechanism 2; 18.  |  1981. Barbara Rohm,aKirstin Scherlachaand Christian Hertweck*a,b aLeibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr. In mammals there are four paralogous ANT genes, of which ANT4 is exclusively expressed in meiotic germ cells. Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or mitochondrial ADP/ATP carrier, exchanges free ATP with free ADP across the inner mitochondrial membrane. Both compounds are currently being trialled in patients with solid tumours. Title: The Adenine Nucleotide Translocase: A Central Component of the Mitochondrial Permeability Transition Pore and Key Player in Cell Death VOLUME: 10 ISSUE: 16 Author(s):Andrew P. Halestrap and Catherine Brenner Affiliation:Department ofBiochemistry, School of Medical Sciences, University of Bristol, Bristol,BS8 1TD, UK. Adenine nucleotide translocase-2 (ANT2) is an oncogenic mitochondrial membrane–associated protein. ANT, adenine nucleotide translocase; TTFA, thenoyltrifluoroacetone; FCCP, carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone; MPTP, mitochondrial permeability transition pore. We use cookies to help provide and enhance our service and tailor content and ads. Here, we describe the characterization of adenine nucleotide translocase-1 (ANT-1), a central component of the permeability transition pore, which was identified using such a screen. Crossref, Medline, Google Scholar; Zamora M, Merono C, Vinas O, Mampel T (2004b). In addition, ANT can cooperate with Bax to form a lethal pore during apoptosis. 2016; 15(6):1387-96 … The possibility that inhibition by fatty acid, acylCoA, and acylcarnitine could be attributed to non-specific detergency effects seems remote in that these compounds were more potent inhibitors of AdNT than equimolar concentrations of laurylsulfate. Pharmacol Ther. Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase(ANT), ADP/ATP carrier protein (AAC) or mitochondrial ADP/ATP carrier, exchanges free ATP with free ADP across the inner mitochondrial membrane. Humans possess four distinct ANT isoforms, encoded by four … It has been concluded that operation of adenine nucleotide translocation in mitochondria of tested fungi is obligatory both for normal spore germination and fungal growth. This assignment is supported by the finding that carboxyatractyloside, a specific inhibitor of the adenine nucleotide translocase, can prevent the oxidant-induced changes in the 28-kDa protein. Both compounds are currently being trialled in patients with solid tumours. ANT has two conformational states, c-state and m-state, and ADP/ATP are transported via interconversion of these two states. In this study we investigated the influence of the adenine nucleotide translocase (ANT) inhibitors–carboxyatractyloside (CAT) and bongkrekic acid (BA)–on the diazoxide- and pinacidil … In addition, ANT can cooperate with Bax to form a lethal pore during apoptosis. Both compounds are currently being trialled in patients with solid tumours. 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